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Sci Rep. 2018 Apr 18;8(1):6182. doi: 10.1038/s41598-018-24592-9.

IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population.

Zha LF1,2, Nie SF1,2, Chen QW1,2, Liao YH1,2, Zhang HS1,2, Dong JT1,2, Xie T1,2, Wang F3, Tang TT1,2, Xia N1,2, Xu CQ4, Zhou YC4, Zeng ZP1,2, Jiao J1,2, Wang PY1,2, Wang QK4, Tu X5, Cheng X6,7.

Author information

1
Department of cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
2
Key Lab for biological targeted therapy of Education Ministry and Hubei province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
3
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
4
Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, 430074, China.
5
Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, 430074, China. xtu@hust.edu.cn.
6
Department of cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. nathancx@mail.hust.edu.cn.
7
Key Lab for biological targeted therapy of Education Ministry and Hubei province, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. nathancx@mail.hust.edu.cn.

Abstract

Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457C-rs2069744T-rs20541A) significantly contributed to the risk of CAD with adjusted p values less than 0.05 (padj = 0.019 and padj = 0.042, respectively). In subgroup population analyses, the variant rs1881457C was found to significantly contribute to a nearly two fold increase in the risk of CAD in men (padj = 0.023, OR = 1.91, 95% CI: 1.09-3.33). The variant rs1881457C also significantly contributed to a nearly twofold risk of late-onset CAD (padj = 0.024, OR = 1.93, 95% CI: 1.09-3.42). In conclusion, IL13 might be involved in CAD via different mechanisms under different conditions in the Chinese Han population.

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