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PLoS One. 2018 Apr 18;13(4):e0195658. doi: 10.1371/journal.pone.0195658. eCollection 2018.

Age at natural menopause and associated factors in adult women: Findings from the China Kadoorie Biobank study in Zhejiang rural area.

Author information

1
Department of NCDs Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
2
Chinese Academy of Medical Sciences, Dong Cheng District, Beijing, China.
3
Department of Epidemiology, School of Public Health, Peking University Health Science Center, Haidian District, Beijing, China.
4
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Abstract

OBJECTIVES:

To investigate the factors associated with age at natural menopause in a large population of Chinese adult women.

METHODS:

This cross-sectional study was part of the baseline survey of China Kadoorie Biobank in Zhejiang Province. A total of 17,076 postmenopausal women were included in the present study. Relevant data of socio-demographic, lifestyle, dietary and reproductive characteristics were collected. Multinomial logistic regression models were used to examine the associated factors of age at natural menopause with adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were reported.

RESULTS:

The mean age at natural menopause was 48.94 years, with 3.40% of the women experienced premature menopause and 6.75% early menopause. Younger age, higher education, consumption of meat (1-3 days per week) and increased parity were associated with late menopause. Current smoking, underweight, higher physical activity, consumption of sea food (1-3 days per week), fresh eggs (≥4 days per week), fresh fruits (≥1 day per week), taking vitamins, experiencing severe food shortage, earlier age at menarche and older age at first birth were associated with earlier age at natural menopause.

CONCLUSIONS:

These results suggest that certain factors involved with socio-demographic, lifestyle, dietary and reproductive characteristics are related to the age at natural menopause in Chinese women.

PMID:
29668705
PMCID:
PMC5905992
DOI:
10.1371/journal.pone.0195658
[Indexed for MEDLINE]
Free PMC Article

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