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PLoS One. 2018 Apr 18;13(4):e0194829. doi: 10.1371/journal.pone.0194829. eCollection 2018.

Aspirin use and long-term rates of sepsis: A population-based cohort study.

Author information

1
University of Alabama School of Medicine, Birmingham, Alabama, United States of America.
2
Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama, United States of America.
3
Division of Preventive Medicine, Department of Medicine, University of Alabama School of Medicine, Birmingham, Alabama, United States of America.
4
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
5
Department of Medicine, Weill Cornell Medical College, New York, NY, United States of America.
6
Department of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.

Abstract

OBJECTIVE:

Sepsis is the syndrome of life-threatening organ dysfunction resulting from dysregulated host response to infection. Aspirin, an anti-inflammatory agent, may play a role in attenuating the inflammatory response during infection. We evaluated the association between aspirin use and long-term rates of sepsis as well as sepsis outcomes.

METHODS:

We analyzed data from 30,239 adults ≥45 years old in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. The primary exposure was aspirin use, identified via patient interview. The primary outcome was sepsis hospitalization, defined as admission for infection with two or more systemic inflammatory response syndrome criteria. We fit Cox proportional hazards models assessing the association between aspirin use and rates of sepsis, adjusted for participant demographics, health behaviors, chronic medical conditions, medication adherence, and biomarkers. We used a propensity-matched analysis and a series of sensitivity analyses to assess the robustness of our results. We also examined risk of organ dysfunction and hospital mortality during hospitalization for sepsis.

RESULTS:

Among 29,690 REGARDS participants with follow-up data available, 43% reported aspirin use (n = 12,869). Aspirin users had higher sepsis rates (hazard ratio 1.35; 95% CI: 1.22-1.49) but this association was attenuated following adjustment for potential confounders (adjusted HR 0.99; 95% CI: 0.88-1.12). We obtained similar results in propensity-matched and sensitivity analyses. Among sepsis hospitalizations, aspirin use was not associated with organ dysfunction or hospital death.

CONCLUSIONS:

In the REGARDS cohort, baseline aspirin use was not associated with long-term rates of sepsis.

PMID:
29668690
PMCID:
PMC5905958
DOI:
10.1371/journal.pone.0194829
[Indexed for MEDLINE]
Free PMC Article

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