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Asian J Androl. 2018 May-Jun;20(3):244-252. doi: 10.4103/aja.aja_14_18.

Vitamin D in prostate cancer.

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Inova Schar Cancer Institute, Inova Health System, Fairfax, VA 22037, USA.


Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.


CYP24A1; androgens; inflammation; prostate cancer; vitamin D analogs

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