Format

Send to

Choose Destination
J Endocrinol Invest. 2019 Jan;42(1):85-90. doi: 10.1007/s40618-018-0889-x. Epub 2018 Apr 17.

Lack of association between obesity and aggressiveness of differentiated thyroid cancer.

Author information

1
Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico, 155, 00161, Rome, RM, Italy.
2
Unità di Medicina Nucleare, Sapienza Università di Roma, Rome, Italy.
3
Dipartimento di Scienze della Salute, Università di Catanzaro "Magna Graecia", Catanzaro, Italy.
4
Dipartimento di Scienze Chirurgiche, Sapienza Università di Roma, Rome, Italy.
5
Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico, 155, 00161, Rome, RM, Italy. cosimo.durante@uniroma1.it.

Abstract

PURPOSE:

Aim of this study was to evaluate the association between body mass index (BMI) and aggressive features of differentiated thyroid cancer (DTC) in a prospective cohort.

METHODS:

Patients with DTC were prospectively enrolled at a tertiary referral center and grouped according to their BMI. Aggressive clinic-pathological features were analyzed following the American Thyroid Association Initial Risk Stratification System score.

RESULTS:

The cohort was composed of 432 patients: 5 (1.2%) were underweight, 187 (43.3%) normal weight, 154 (35.6%) overweight, 68 (15.7%) grade 1 obese, 11 (2.5%) grade 2 obese and 7 (1.6%) grade 3 obese. No single feature of advanced thyroid cancer was more frequent in obese patients than in others. No significant correlation was found between BMI, primary tumor size (Spearman's ρ - 0.02; p = 0.71) and ATA Initial Risk Stratification System score (ρ 0.03; p = 0.49), after adjustment for age. According to the multivariate logistic regression analysis, male gender and pre-surgical diagnosis of cancer were significant predictors of cancer with high or intermediate-high recurrence risk according to the ATA system (OR 2.06 and 2.51, respectively), while older age at diagnosis was a protective factor (OR 0.98), and BMI was not a predictor. BMI was a predictor of microscopic extrathyroidal extension only (OR 1.06).

CONCLUSIONS:

Obesity was not associated with aggressive features in this prospective, European cohort of patients with DTC.

KEYWORDS:

Advanced stage; Aggressive cancer; Body mass index; Cancer size; Obesity; Thyroid cancer

PMID:
29667113
DOI:
10.1007/s40618-018-0889-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center