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Curr Cardiol Rep. 2018 Apr 17;20(6):38. doi: 10.1007/s11886-018-0984-9.

Genome Editing and Induced Pluripotent Stem Cell Technologies for Personalized Study of Cardiovascular Diseases.

Author information

1
Departments of Medicine - Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, PRB 383, Nashville, TN, 37232, USA.
2
Department of Pediatrics - Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
3
Departments of Medicine - Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, PRB 383, Nashville, TN, 37232, USA. charles.c.hong@vanderbilt.edu.

Abstract

PURPOSE OF REVIEW:

The goal of this review is to highlight the potential of induced pluripotent stem cell (iPSC)-based modeling as a tool for studying human cardiovascular diseases. We present some of the current cardiovascular disease models utilizing genome editing and patient-derived iPSCs.

RECENT FINDINGS:

The incorporation of genome-editing and iPSC technologies provides an innovative research platform, providing novel insight into human cardiovascular disease at molecular, cellular, and functional level. In addition, genome editing in diseased iPSC lines holds potential for personalized regenerative therapies. The study of human cardiovascular disease has been revolutionized by cellular reprogramming and genome editing discoveries. These exceptional technologies provide an opportunity to generate human cell cardiovascular disease models and enable therapeutic strategy development in a dish. We anticipate these technologies to improve our understanding of cardiovascular disease pathophysiology leading to optimal treatment for heart diseases in the future.

KEYWORDS:

Cardiomyocytes; Cardiovascular disease; Genome editing; Induced pluripotent stem cells; Personalized medicine

PMID:
29666931
PMCID:
PMC6204334
[Available on 2019-04-17]
DOI:
10.1007/s11886-018-0984-9

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