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J Food Sci Technol. 2018 May;55(5):1880-1888. doi: 10.1007/s13197-018-3105-2. Epub 2018 Mar 14.

Antiglycation and antioxidant activities of mogroside extract from Siraitia grosvenorii (Swingle) fruits.

Liu H1,2, Wang C3, Qi X2,4, Zou J2, Sun Z1.

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1College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070 People's Republic of China.
3College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100 People's Republic of China.
Shanghai OPM Biosciences Co., Ltd., Shanghai, 201321 People's Republic of China.
4Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, 100048 People's Republic of China.


Siraitia grosvenorii (Swingle) is one kind of medical and edible plants with various health-promoting properties. Recently, its hypoglycemic and antidiabetic activities have been reported, but the underlying mechanism remains to be explored. The current study was aimed to investigate the antioxidant and antiglycation activities of mogroside extract (MGE) from Siraitia grosvenorii (Swingle). The results showed that compared to glycated BSA, MGE at middle (125 μg/mL) and high dose (500 μg/mL) significantly inhibited BSA glycation evidenced by decreased fluorescent AGEs formation, protein carbonyls and Nε-(carboxymethyl) lysine (CML) level at 500 μg/mL by 58.5, 26.7 and 71.2%, respectively. Additionally, the antiglycative activity of MGE (500 μg/mL) was comparable to aminoguanidine (AG) at the equal concentration. However, the inhibitory effect of MGE on glycation-induced increase of fructosamine level and decrease of thiol level was not remarkable. MGE was a potent peroxide radicals scavenger (851.8 μmol TE/g), moderate DPPH and ABTS radicals scavenger with IC50 1118.1 and 1473.2 μg/mL, respectively, corresponding to positive controls ascorbic acid of IC50 9.6 μg/mL, and trolox of IC50 47.9 μg/mL, respectively, and mild reducing power. These findings suggest that MGE may serve as a new promising antiglycative agent against diabetic complications by inhibiting protein glycation and glycoxidation.


Antiglycation; Antioxidant; Cucurbitane triterpene glycosides; Siraitia grosvenorii (Swingle)

[Available on 2019-05-01]

Conflict of interest statement

Compliance with ethical standardsThe authors declare that there are no competing interests.

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