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Nat Rev Neurosci. 2018 Jun;19(6):323-337. doi: 10.1038/s41583-018-0001-8.

Intrinsic mechanisms of neuronal axon regeneration.

Author information

1
Department of Neuroscience, Hope Center for Neurological Disorders and Center of Regenerative Medicine, Washington University School of Medicine, St Louis, MO, USA.
2
Department of Neuroscience, Hope Center for Neurological Disorders and Center of Regenerative Medicine, Washington University School of Medicine, St Louis, MO, USA. cavalli@wustl.edu.

Abstract

Permanent disabilities following CNS injuries result from the failure of injured axons to regenerate and rebuild functional connections with their original targets. By contrast, injury to peripheral nerves is followed by robust regeneration, which can lead to recovery of sensory and motor functions. This regenerative response requires the induction of widespread transcriptional and epigenetic changes in injured neurons. Considerable progress has been made in recent years in understanding how peripheral axon injury elicits these widespread changes through the coordinated actions of transcription factors, epigenetic modifiers and, to a lesser extent, microRNAs. Although many questions remain about the interplay between these mechanisms, these new findings provide important insights into the pivotal role of coordinated gene expression and chromatin remodelling in the neuronal response to injury.

PMID:
29666508
PMCID:
PMC5987780
DOI:
10.1038/s41583-018-0001-8
[Indexed for MEDLINE]
Free PMC Article

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