Format

Send to

Choose Destination
Sci Rep. 2018 Apr 17;8(1):6114. doi: 10.1038/s41598-018-24525-6.

Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice.

Author information

1
Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.
2
St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.
3
Cardiac Regeneration Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.
4
Department of Surgery, Emory University School of Medicine, Atlanta, GA, 30308, USA.
5
Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
6
Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia. b.graham@victorchang.edu.au.
7
St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2052, Australia. b.graham@victorchang.edu.au.

Abstract

We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted overexpression of the dominant negative W v mutant protein (dn-c-kit-Tg) respond to pressure overload with robust cardiomyocyte (CM) cell cycle entry. Here, we tested if outcomes after myocardial infarction (MI) due to coronary artery ligation are improved in this transgenic model. Compared to non-transgenic littermates (NTLs), adult male dn-c-kit-Tg mice displayed CM hypertrophy and concentric left ventricular (LV) hypertrophy in the absence of an increase in workload. Stroke volume and cardiac output were preserved and LV wall stress was markedly lower than that in NTLs, leading to a more energy-efficient heart. In response to MI, infarct size in adult (16-week old) dn-c-kit-Tg hearts was similar to that of NTL after 24 h but was half that in NTL hearts 12 weeks post-MI. Cumulative CM cell cycle entry was only modestly increased in dn-c-kit-Tg hearts. However, dn-c-kit-Tg mice were more resistant to infarct expansion, adverse LV remodelling and contractile dysfunction, and suffered no early death from LV rupture, relative to NTL mice. Thus, pre-existing cardiac hypertrophy lowers wall stress in dn-c-kit-Tg hearts, limits infarct expansion and prevents death from myocardial rupture.

PMID:
29666426
PMCID:
PMC5904135
DOI:
10.1038/s41598-018-24525-6
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center