Format

Send to

Choose Destination
Immunol Rev. 2018 May;283(1):129-137. doi: 10.1111/imr.12646.

TCR tuning of T cell subsets.

Author information

1
Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Korea.
2
Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Korea.
3
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

Abstract

After selection in the thymus, the post-thymic T cell compartments comprise heterogenous subsets of naive and memory T cells that make continuous T cell receptor (TCR) contact with self-ligands bound to major histocompatibility complex (MHC) molecules. T cell recognition of self-MHC ligands elicits covert TCR signaling and is particularly important for controlling survival of naive T cells. Such tonic TCR signaling is tightly controlled and maintains the cells in a quiescent state to avoid autoimmunity. Here, we review how naive and memory T cells are differentially tuned and wired for TCR sensitivity to self and foreign ligands.

KEYWORDS:

CD45; CD5; T cell receptor; TCR tuning; major histocompatibility complex molecules; self-peptides

PMID:
29664578
DOI:
10.1111/imr.12646
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center