Format

Send to

Choose Destination
Nat Neurosci. 2018 May;21(5):744-756. doi: 10.1038/s41593-018-0130-4. Epub 2018 Apr 16.

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures.

Author information

1
Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK. mccaffertycp@cardiff.ac.uk.
2
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA. mccaffertycp@cardiff.ac.uk.
3
Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.
4
Team Waking, Lyon Neuroscience Research Center, CRNL, INSERM U1028, CNRS UMR5292, University of Lyon 1, Lyon, France.
5
Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
6
Department of Physiology and Biochemistry, University of Malta, Msida, Malta.
7
Sorbonne Université, CNRS, Inserm, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris, France.
8
Neuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK. crunelli@cardiff.ac.uk.
9
Department of Physiology and Biochemistry, University of Malta, Msida, Malta. crunelli@cardiff.ac.uk.

Abstract

Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channel (T-channel)-dependent burst firing in thalamocortical (TC) neurons and by temporally framing thalamic output via feedforward reticular thalamic (NRT)-to-TC neuron inhibition. In TC neurons, overall ictal firing was markedly reduced and bursts rarely occurred. Moreover, blockade of T-channels in cortical and NRT neurons suppressed ASs, but such blockade in TC neurons had no effect on seizures or on ictal thalamic output synchrony. These results demonstrate ictal bidirectional cortico-thalamic communications and provide the first mechanistic understanding of cortico-thalamo-cortical network firing dynamics during ASs in behaving animals.

Comment in

PMID:
29662216
PMCID:
PMC6278913
DOI:
10.1038/s41593-018-0130-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center