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Clin Transl Sci. 2018 Jul;11(4):352-364. doi: 10.1111/cts.12551. Epub 2018 Apr 16.

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.

Fisel P1,2, Schaeffeler E1,2, Schwab M1,2,3,4,5.

Author information

1
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
2
University of Tübingen, Tübingen, Germany.
3
Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany.
4
Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.
5
German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Abstract

The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and distribution of monocarboxylic compounds across plasma membranes. As the knowledge about their physiological function, activity, and regulation increases, their involvement and contribution to cancer and other diseases become increasingly evident. Moreover, promising opportunities for therapeutic interventions by directly targeting their endogenous functions or by exploiting their ability to deliver drugs to specific organ sites emerge.

PMID:
29660777
PMCID:
PMC6039204
DOI:
10.1111/cts.12551
[Indexed for MEDLINE]
Free PMC Article

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