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Endocrinology. 2018 Jun 1;159(6):2275-2287. doi: 10.1210/en.2018-00147.

Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice.

Author information

1
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.
2
Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
3
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
4
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
5
Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Haifa, Israel.
6
Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, Michigan.

Abstract

The purpose of this study was to determine the effects of glucocorticoid-induced metabolic dysfunction in the presence of diet-induced obesity. C57BL/6J adult male lean and diet-induced obese mice were given dexamethasone, and levels of hepatic steatosis, insulin resistance, and lipolysis were determined. Obese mice given dexamethasone had significant, synergistic effects on fasting glucose, insulin resistance, and markers of lipolysis, as well as hepatic steatosis. This was associated with synergistic transactivation of the lipolytic enzyme adipose triglyceride lipase. The combination of chronically elevated glucocorticoids and obesity leads to exacerbations in metabolic dysfunction. Our findings suggest lipolysis may be a key player in glucocorticoid-induced insulin resistance and fatty liver in individuals with obesity.

PMID:
29659785
PMCID:
PMC5946848
[Available on 2019-06-01]
DOI:
10.1210/en.2018-00147
[Indexed for MEDLINE]

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