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Mar Drugs. 2018 Apr 16;16(4). pii: E130. doi: 10.3390/md16040130.

Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment.

Author information

1
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea. rlaekdud0503@naver.com.
2
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea. ejlee@dgmif.re.kr.
3
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea. jl3414@gmail.com.
4
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea. leutoualain@yahoo.fr.
5
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 08826, Korea. itsue00@snu.ac.kr.
6
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea. bomeec87@naver.com.
7
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea. hjs1228@dgmif.re.kr.
8
School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea. dohahn@knu.ac.kr.
9
Institute of Agricultural Science & Technology, Kyungpook National University, Daegu 41566, Korea. dohahn@knu.ac.kr.
10
College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbukdo 38541, Korea. h5choi@yu.ac.kr.
11
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea. jwchin@dgmif.re.kr.
12
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea. sjcho@dgmif.re.kr.
13
Materials Lab Amorepacific R&D Unit, Yongin, Gyeonggi-do 17074, Korea. hydhong@amorepacific.com.
14
Materials Lab Amorepacific R&D Unit, Yongin, Gyeonggi-do 17074, Korea. jaeyoungko@amorepacific.com.
15
Department of Biology, College of Life Science and Natural Resource, Sunchon National University, Suncheon 57922, Korea. scnu@sunchon.ac.kr.
16
Department of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, CA 92106, USA. KatherineMaloney@pointloma.edu.
17
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 08826, Korea. dongchanoh@snu.ac.kr.
18
Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea. ihyang@kmou.ac.kr.
19
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea. hwanghy@dgmif.re.kr.
20
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea. sjnam@ewah.ac.kr.

Abstract

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

KEYWORDS:

Streptomyces sp.; cold water natural product; marine natural product; zizaane-type sesquiterpenoid

PMID:
29659509
PMCID:
PMC5923417
DOI:
10.3390/md16040130
[Indexed for MEDLINE]
Free PMC Article

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