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CNS Oncol. 2018 Apr;7(2):CNS17. doi: 10.2217/cns-2017-0030. Epub 2018 Apr 16.

The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

Author information

1
Institute of Translational Medicine, University of Liverpool & The Walton Center NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK.
2
Department of Biostatistics, University of Liverpool, Brownlow Hill, Liverpool L69 3BX, UK.

Abstract

AIM:

We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas.

METHODS:

The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors.

RESULTS:

No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias. All studies reported overall or progression-free survival; however the effectiveness of KD interventions could not be established. Dietary acceptability was not reported.

CONCLUSION:

The effectiveness and acceptability of KDs in the management of gliomas is unknown and high quality randomized controlled trials are needed.

KEYWORDS:

glioblastoma; glioma; ketogenic diet; systematic review

PMID:
29658772
PMCID:
PMC5977276
DOI:
10.2217/cns-2017-0030
[Indexed for MEDLINE]
Free PMC Article

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