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Noncoding RNA. 2018 Mar 8;4(1). pii: E7. doi: 10.3390/ncrna4010007.

The Role of Long Non-Coding RNAs in Osteosarcoma.

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Department of Orthopaedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria.
Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Division of Cancer Medicine, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.


Long non-coding RNAs (lncRNAs) constitute non-protein coding transcripts with a size > than 200 nucleotides. They are involved in many cellular processes, such as chromatin remodelling, transcription, and gene expression. They play a role in the development, progression, and invasion of many human cancers, including osteosarcoma. This rare tumor entity predominantly arises in children and young adults. Treatment consists of polychemotherapy and surgical resection, increasing survival rates up to 60%. In the present review, the role of lncRNAs with prognostic, predictive, therapeutic, and diagnostic significance in osteosarcoma is discussed. Moreover, their potential application in clinical practice is highlighted.


lncRNA; osteosarcoma; pathogenesis

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