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Neuron. 2018 May 2;98(3):602-615.e8. doi: 10.1016/j.neuron.2018.03.037. Epub 2018 Apr 12.

Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex.

Author information

1
Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: m.dipoppa@ucl.ac.uk.
2
Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
3
Institute of Neurology, University College London, London WC1N 3BG, UK.

Abstract

Cortical computation arises from the interaction of multiple neuronal types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such interactions, we imaged these four types of cells in mouse primary visual cortex (V1). Our recordings in darkness were consistent with a "disinhibitory" model in which locomotion activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when visual stimuli were present: locomotion increased Sst cell responses to large stimuli and Vip cell responses to small stimuli. A recurrent network model successfully predicted each cell type's activity from the measured activity of other types. Capturing the effects of locomotion, however, required allowing it to increase feedforward synaptic weights and modulate recurrent weights. This network model summarizes interneuron interactions and suggests that locomotion may alter cortical computation by changing effective synaptic connectivity.

KEYWORDS:

circuit; disinhibition; inhibition; inhibition stabilized network; interneurons; locomotion; neural field model; primary visual cortex; recurrence; surround suppression

PMID:
29656873
PMCID:
PMC5946730
DOI:
10.1016/j.neuron.2018.03.037
[Indexed for MEDLINE]
Free PMC Article

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