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Trends Biochem Sci. 2018 Jun;43(6):395-397. doi: 10.1016/j.tibs.2018.03.009. Epub 2018 Apr 12.

Metabolite Depletion Affects Flux Profiling of Cell Lines.

Author information

1
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg SE41296, Sweden.
2
Systems Bioinformatics, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
3
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg SE41296, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK2800 Kongens Lyngby, Denmark. Electronic address: nielsenj@chalmers.se.

Abstract

Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

KEYWORDS:

cancer; glutamine; metabolic modeling; serine

PMID:
29656822
DOI:
10.1016/j.tibs.2018.03.009
[Indexed for MEDLINE]

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