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Development. 2018 Apr 13;145(8). pii: dev158360. doi: 10.1242/dev.158360.

p53: emerging roles in stem cells, development and beyond.

Author information

1
Department of Epigenetics and Molecular Carcinogenesis, Center for Stem Cell and Development Biology, Center for Cancer Epigenetics, The University of Texas MD Anderson UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA ajain@mdanderson.org mbarton@mdanderson.org.

Abstract

Most human cancers harbor mutations in the gene encoding p53. As a result, research on p53 in the past few decades has focused primarily on its role as a tumor suppressor. One consequence of this focus is that the functions of p53 in development have largely been ignored. However, recent advances, such as the genomic profiling of embryonic stem cells, have uncovered the significance and mechanisms of p53 functions in mammalian cell differentiation and development. As we review here, these recent findings reveal roles that complement the well-established roles for p53 in tumor suppression.

KEYWORDS:

Development; Differentiation; Embryonic stem cells; lncRNA; p53

PMID:
29654218
DOI:
10.1242/dev.158360
[Indexed for MEDLINE]
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