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Psychiatry Res. 2018 Jun;264:210-216. doi: 10.1016/j.psychres.2018.03.058. Epub 2018 Mar 29.

Relevance of treated cocaine users' retrospective memory of first cocaine use.

Author information

1
APHP, Hôpital Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, 200 rue du Fg St Denis, 75010 Paris, France; Inserm Umr-s 1144 Variabilité de réponse aux psychotropes, 4 avenue de l'Observatoire, 75006 Paris, France; EA 4430 CLIPSYD Clinique Psychanalyse Développement, Département de Sciences Psychologiques et Sciences de l'Education, Université Paris Nanterre, 200, Avenue de la République, 92001 Nanterre Cedex, France. Electronic address: Emily.karsinti@aphp.fr.
2
APHP, Hôpital Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, 200 rue du Fg St Denis, 75010 Paris, France.
3
Inserm Umr-s 1144 Variabilité de réponse aux psychotropes, 4 avenue de l'Observatoire, 75006 Paris, France.
4
Neurobiologie intégrative des systèmes cholinergiques, CNRS UMR 3571, Département de Neuroscience, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France.
5
Neuroscience Paris-Seine - IBPS, UPMC UM CR18 - CNRS UMR 8246 - INSERM U1130, Equipe Neurophysiologie et Comportement (NPC), Boite 16, Universite P. et M. Curie, 9 quai St Bernard, 75005, Paris, France.
6
EA 4430 CLIPSYD Clinique Psychanalyse Développement, Département de Sciences Psychologiques et Sciences de l'Education, Université Paris Nanterre, 200, Avenue de la République, 92001 Nanterre Cedex, France.
7
APHP, Hôpital Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, 200 rue du Fg St Denis, 75010 Paris, France; Faculté de Médecine, Université Paris Diderot, 16 rue Huchard, 75018 Paris, France; Inserm Umr-s 1144 Variabilité de réponse aux psychotropes, 4 avenue de l'Observatoire, 75006 Paris, France.
8
NPsy-Sydo, Neuro-psycho-pharmacologie des systèmes dopaminergiques sous-corticaux, EA 7280, U.F.R. Médecine Université Clermont-Auvergne, CHU Gabriel-Montpied, 58, rue Montalembert, 63003 Clermont-Ferrand, France.

Abstract

Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21.5% of questionnaire variance), Disinhibition (17.3%), Tachypsychia (16%) and Calmness (13%). Male gender was associated with Disinhibition and Tachypsychia. Cocaine severity factors were associated with Disinhibition, Tachypsychia and Calmness. Opiate, sedative and poppers uses were associated with Anxiety, Tachypsychia and Calmness. The retrospective assessment of the subjective effects of first cocaine use shows significant variability. The different dimensions of subjective first effects are influenced by age, gender and previous substance use history, as well as characteristics of first cocaine use and cocaine-related outcomes.

KEYWORDS:

Cocaine; First use; Outcome; Subjective effects

PMID:
29653350
DOI:
10.1016/j.psychres.2018.03.058
[Indexed for MEDLINE]

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