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Nutrients. 2018 Apr 13;10(4). pii: E484. doi: 10.3390/nu10040484.

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats.

Author information

1
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain. madopaca@um.es.
2
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain. paodunromec@gmail.com.
3
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain. ntma@um.es.
4
Departamento de Anatomía Patológica, Facultad de Medicina, IBIMER, ibs.Granada, Universidad de Granada, 18011 Granada, Spain. fovalle@ugr.es.
5
Instituto Universitario de Envejecimiento & Research and Development Department, Nutrafur SA-FRUTAROM Group, 30820 Alcantarilla (Murcia), Spain. j.castillo@nutrafur.com.
6
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain. clara@um.es.
7
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain. jgestan@um.es.

Abstract

BACKGROUND:

we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME.

METHODS:

Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks.

RESULTS:

L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage.

CONCLUSIONS:

the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.

KEYWORDS:

acetylcholine; flavonoids; heart; kidney; nitric oxide; phenylephrine; sodium balance

PMID:
29652818
PMCID:
PMC5946269
DOI:
10.3390/nu10040484
[Indexed for MEDLINE]
Free PMC Article

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