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Exerc Sport Sci Rev. 2018 Jul;46(3):195-202. doi: 10.1249/JES.0000000000000152.

Potential Roles of Vascular Endothelial Growth Factor During Skeletal Muscle Hypertrophy.

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1
College of Pharmacy and Health Sciences, Drake University, Des Moines, IA.

Abstract

Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review explores the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-ß-catenin.

PMID:
29652692
DOI:
10.1249/JES.0000000000000152
[Indexed for MEDLINE]

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