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J Pediatr Endocrinol Metab. 2018 Apr 25;31(5):503-506. doi: 10.1515/jpem-2017-0463.

Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents.

Author information

1
Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Yeongtong-gu, Suwon, Republic of Korea.
2
Department of Pediatrics, Wonkwang University School of Medicine, Wonkwang University Hospital, Iksan, Jeonbuk, Republic of Korea.
3
Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Republic of Korea, Phone: +82-31-219-5166, Fax: +82-31-219-5169.

Abstract

BACKGROUND:

The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far.

METHODS:

A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obese children and adolescents aged 4-17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results.

RESULTS:

A glycated hemoglobin (HbA1c) level of 6.5% had a sensitivity and specificity of 87.2% and 98.5%, respectively, for detecting T2DM. The optimal HbA1c cutoff level for T2DM was >6.2% (94.7% sensitivity, 95.5% specificity).

CONCLUSIONS:

We observed that the use of an HbA1c level of 6.5% had a lower sensitivity for detecting T2DM than an HbA1c level of >6.2%.

KEYWORDS:

HbA1c; obesity; pediatrics; screening; type 2 diabetes

PMID:
29652667
DOI:
10.1515/jpem-2017-0463
[Indexed for MEDLINE]

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