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Urologe A. 2018 May;57(5):558-562. doi: 10.1007/s00120-018-0636-0.

[Cannabinoid therapy in practice].

[Article in German]

Author information

1
Zentrum für Seltene Erkrankungen (ZSEB), Universitätsklinikum Bonn, Bonn, Deutschland.
2
Zentrum für Seltene Erkrankungen (ZSEB), Universitätsklinikum Bonn, Bonn, Deutschland. martin.muecke@ukbonn.de.
3
Institut für Hausarztmedizin, Universitätsklinikum Bonn, Bonn, Deutschland. martin.muecke@ukbonn.de.
4
Klinik für Palliativmedizin, Universitätsklinikum Bonn, Bonn, Deutschland. martin.muecke@ukbonn.de.
5
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Bonn, Bonn, Deutschland.

Abstract

BACKGROUND:

In recent years, the media and scientists have shown increased interest in cannabis-based drugs.

OBJECTIVES:

Background information about cannabis-based drugs and their mechanism of action as well as discussion of possible applications as supportive therapy or in palliative medicine, respectively, are presented.

MATERIALS AND METHODS:

The recent literature was examined and evaluated.

RESULTS:

In many medical fields, we do not have sufficient evidence for the efficacy of cannabinoids. In German pharmaceutical legislation, the use of nabiximols for the treatment of intermediate to severe, therapy-resistant spasticity in multiple sclerosis is the only approved indication for cannabis-based drugs. Furthermore, in view of the current evidence cannabinoids, combined with established treatments and as part of an individual therapeutic attempt, can be used for neuropathic pain, cancer-associated pain and human immunodeficiency virus (HIV)-related cachexia.

CONCLUSIONS:

In most cases, today's assessment of cannabinoids relies on studies that are classified as low evidence. Therefore, further studies which involve more participants and evaluate long-term effects are needed.

KEYWORDS:

Anesthetics; Cannabidiol; Cannabinoid receptor; Palliative care; Palliative medicine

PMID:
29651709
DOI:
10.1007/s00120-018-0636-0
[Indexed for MEDLINE]

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