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Indian J Clin Biochem. 2018 Apr;33(2):190-195. doi: 10.1007/s12291-017-0666-1. Epub 2017 May 18.

Effects of Alternanthera sessilis on Liver Function in Carbon Tetra Chloride Induced Hepatotoxicity in Wister Rat Model.

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1
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004 India.

Abstract

Alternanthera sessilis commonly known as 'sessile joy weed' or 'dwarf copperleaf' is found throughout the hotter parts of India up to an altitude of 1200 m2. In Assam, the plant has been traditionally used in the treatment of jaundice along with other ailments. The study focuses primarily on the evaluation of hepatoprotective activity of the plant with special references to its putative protective role in carbon tetrachloride induced liver injury on Wister albino rat. The in vivo hepatoprotective activity of the methanolic extract at the dose of 250 mg/kg body weight was highly effective in controlling SGPT, SGOT, ALP, serum cholesterol and serum bilirubin level as compared to silymarin. The said extract also significantly lowered the lipid profile caused by CCl4. The activity shown by methanolic extract of the whole plant of A. sessilis is of considered importance and thus justified its use in controlling hepatic diseases in traditional treatment system.

KEYWORDS:

Alternanthera sessilis; Hepatoprotective; Lipid profile; Methanolic extract

Conflict of interest statement

Compliance with Ethical StandardsAll authors declare that they have no conflict of interests.All procedures performed in studies involving animals were in accordance with the ethical standards promulgated by the Institutional Animal Care Committee, CPCSEA, India. The institutional registration number is 1576/GO/a/11/CPCSE dated: 17/2/2012. The present study is approved vide Approval No. IACE/DU/64 Dated 24/9/2013.

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