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Trends Parasitol. 2018 May;34(5):354-356. doi: 10.1016/j.pt.2018.03.006. Epub 2018 Apr 10.

Mannose Receptor and the Mystery of Nonhealing Leishmania major Infection.

Author information

1
Molecular and Translational Cardiology, Department of Cardiovascular Medicine, University Hospital Münster, Germany; Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic. Electronic address: yahya.sohrabi@ukmuenster.de.
2
Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic. Electronic address: lipoldova@img.cas.cz.

Abstract

Scientists have long puzzled over the ability of Leishmania major Seidman (LmSd) to form nonhealing cutaneous lesions in the face of a strong Th1 response. A recent study identified a population of dermal macrophages that are preferentially infected by LmSd in a mannose receptor 1-, C-type 1 (MRC1/CD206)-dependent manner.

PMID:
29650366
DOI:
10.1016/j.pt.2018.03.006
[Indexed for MEDLINE]

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