Format

Send to

Choose Destination
Environ Int. 2018 Jul;116:43-51. doi: 10.1016/j.envint.2018.03.048. Epub 2018 Apr 9.

Occurrence of 44 elements in human cord blood and their association with growth indicators in newborns.

Author information

1
Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain.
2
Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Spain. Electronic address: octavio.perez@ulpgc.es.
3
Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Spain.

Abstract

There is growing concern about environmental pollution produced by elements, including "emerging" contaminants, such as rare earth elements (REE) and other trace elements (TE), which are extensively and increasingly employed in the manufacture of consumer electronics. Previous research has shown that prenatal exposure to some elements (mainly heavy metals) may be associated with decreased fetal growth and other adverse birth outcomes. Recent studies have also shown that environmental exposure to REE and TE may be related to adverse effects on human health. This cross-sectional study, which included nearly 92% of the births in 2016 in La Palma (Canary Islands, Spain; n = 471), aimed to evaluate the potential adverse health effects exerted by a wide range of elements on newborns. We quantified the levels of 44 elements (including 26 REE and TE) in their umbilical cord blood. Our results showed low or very low levels of most elements. We found an inverse association between antimony (Sb) and birth weight (Spearman's r = -0.106, p = 0.021). A similar trend was observed between nickel (Ni) and birth weight and between chromium (Cr) and birth length, although in this case the significance was borderline. Bismuth appeared as a risk factor for having a birth weight below the tenth percentile in the univariate (OR = 3.30; 95% CI = 1.25-8.78; p = 0.017) and multivariate analyses (OR = 5.20; 95% CI = 1.29-20.91; p = 0.020). When assessing the effect of element mixtures, the sum of Cr, Ni, and Sb appeared as a risk factor for having a birth weight below the tenth percentile in the univariate (OR = 2.41; 95% CI = 1.08-5.35; p = 0.031) and multivariate analyses (OR = 3.84; 95% CI = 1.42-10.39; p = 0.008). Our findings suggest that some inorganic elements-isolated or in mixture-are associated to a lower fetal growth. Additional research is needed to understand the role of inorganic pollutants on fetal development.

KEYWORDS:

Birth weight; Bismuth; E-waste; Heavy metals; Rare earth elements

PMID:
29649776
DOI:
10.1016/j.envint.2018.03.048
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center