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Int J Biol Macromol. 2018 Aug;115:861-870. doi: 10.1016/j.ijbiomac.2018.04.042. Epub 2018 Apr 10.

Transcriptome analysis revealed anti-obesity effects of the Sodium Alginate in high-fat diet -induced obese mice.

Author information

1
College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, People's Republic of China.
2
USDA-ARS, Animal Genomics and Improvement Laboratory, Beltsville, MD 20705, USA.
3
College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province 266003, People's Republic of China. Electronic address: tangqingjuan@ouc.edu.cn.

Abstract

Human obesity and overweight, caused by accumulated of fat, is the most commonly phenomenon from all over the world, especially in Western countries and Chinese mainland during the past three decades. Sodium Alginate, a polysaccharide extracted from brown seaweeds, has been proved its strong ability on body weight loss and anti-inflammatory response. However, no studies have been explored the effects of Sodium Alginate on colonic transcriptome, especially in obese individuals. Therefore, the current study was designed to detect whether Sodium Alginate could remit obesity and ease chronic metabolism disease through strengthening the bio-functionality of the lower intestine, particularly in colon. The data showed after Sodium Alginate gavaged for four weeks, the body weight, fat accumulation, triglyceride and total cholesterol were ameliorated in high fat diet induced obese mice. Sodium Alginate also improved the blood glucose level and lipopolysaccharides in serum. Furthermore, data from RNA sequence indicated that there were significantly changes in several genes, which involved in lipid metabolism and carbohydrate metabolism. In conclusion, these results suggested that Sodium Alginate could effectively suppress obesity and obesity related metabolic syndromes, due to the colonic transcriptome changes.

KEYWORDS:

Colon; High-fat-diet; Obesity; RNA-seq; Sodium Alginate; Transcriptome

PMID:
29649537
DOI:
10.1016/j.ijbiomac.2018.04.042
[Indexed for MEDLINE]

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