Format

Send to

Choose Destination
J R Soc Interface. 2018 Apr;15(141). pii: 20170916. doi: 10.1098/rsif.2017.0916.

Long-range proton-coupled electron transfer in biological energy conversion: towards mechanistic understanding of respiratory complex I.

Author information

1
Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, Garching, Germany ville.kaila@ch.tum.de.

Abstract

Biological energy conversion is driven by efficient enzymes that capture, store and transfer protons and electrons across large distances. Recent advances in structural biology have provided atomic-scale blueprints of these types of remarkable molecular machinery, which together with biochemical, biophysical and computational experiments allow us to derive detailed energy transduction mechanisms for the first time. Here, I present one of the most intricate and least understood types of biological energy conversion machinery, the respiratory complex I, and how its redox-driven proton-pump catalyses charge transfer across approximately 300 Å distances. After discussing the functional elements of complex I, a putative mechanistic model for its action-at-a-distance effect is presented, and functional parallels are drawn to other redox- and light-driven ion pumps.

KEYWORDS:

NADH:ubiquinone oxidoreductase; PCET; bioenergetics; molecular simulations; proton transfer

PMID:
29643224
PMCID:
PMC5938582
DOI:
10.1098/rsif.2017.0916
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center