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BMJ Open. 2018 Apr 10;8(4):e020899. doi: 10.1136/bmjopen-2017-020899.

Metabolic syndrome and its components with neuron-specific enolase: a cross-sectional study in large health check-up population in China.

Author information

1
School of Laboratory Medicine, Wannan Medical College, Wuhu, Anhui Province, China.
2
Medical Examination Center, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu, Anhui Province, China.
3
School of Clinical Medicine, Wannan Medical College, Wuhu, Anhui Province, China.

Abstract

OBJECTIVE:

This study was aimed at investigating the relationship between neuron-specific enolase (NSE) and components of metabolic syndrome (MS).

DESIGN:

Cross-sectional study.

SETTING:

Chinese health check-up population.

PARTICIPANTS:

40 684 health check-up people were enrolled in this study from year 2014 to 2016.

MAIN OUTCOME MEASURES:

OR and coefficient for MS.

RESULTS:

The percentage of abnormal NSE and MS was 26.85% and 8.85%, respectively. There were significant differences in sex, body mass index, drinking habit, triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), blood pressure and MS between low-NSE and high-NSE groups. In logistic regression analysis, elevated NSE was present in MS, higher body mass index, hypertriglyceridaemia, hypertension and low-HDL groups. Stepwise linear analysis showed a negative correlation between NSE and fasting blood glucose (FBG) (<6.0 mmol/L), and a positive correlation between NSE and TGs (<20 mmol/L), systolic blood pressure (75-200 mm Hg), HDL-C (0.75-2.50 mmol/L), diastolic blood pressure (<70 mm Hg) and FBG (6.00-20.00 mmol/L). Furthermore, MS was positively correlated with NSE within the range of 2.00-7.50 ng/mL, but had a negative correlation with NSE within the range of 7.50-23.00 ng/mL.

CONCLUSION:

There are associations between NSE with MS and its components. The result suggests that NSE may be a potential predictor of MS. Further research could be conducted in discussing the potential mechanism involved.

KEYWORDS:

cross-sectional study; metabolic syndrome; neuron specific enolase

PMID:
29643166
PMCID:
PMC5898352
DOI:
10.1136/bmjopen-2017-020899
[Indexed for MEDLINE]
Free PMC Article

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