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Z Hautkr. 1987 Dec 15;62(24):1705-9.

[Contact allergies to antifungal agents].

[Article in German]

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Universit├Ąts-Hautklinik Heidelberg.


Contact allergies to modern antimycotic agents are comparatively rare considering the high prescription rates. They may be caused by components of either the vehicle or the active ingredient. According to both the literature and our own investigations, the most important sensitizers of the vehicle are cetylstearyl alcohol and propylene glycol; as to the active substances, miconazole and nystatin are the most frequent sensitizers of the imidazole and non-imidazole group, respectively. Cross-reactions of imidazole derivatives mainly occur between miconazole and econazole. For patch testing with imidazoles, we recommend a 1% alcoholic solution of the active ingredient.

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