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Saudi J Gastroenterol. 2018 Mar-Apr;24(2):109-114. doi: 10.4103/sjg.SJG_438_17.

Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial.

Author information

1
Department of Pediatrics, Faculty of Medicine, Tanta University, Egypt.
2
Tropical Medicine, Faculty of Medicine, Tanta University, Egypt.
3
Clinical Pathology, Faculty of Medicine, Tanta University, Egypt.

Abstract

Background/Aim:

Vitamin D deficiency is common in irritable bowel syndrome (IBS). There is growing interest in the role of vitamin D in pediatric IBS. We aimed to evaluate the effect of vitamin D supplementation in adolescents with IBS and vitamin D deficiency.

Patients and Methods:

One hundred and twelve adolescents with IBS and vitamin D deficiency were randomly divided into two groups of matched age and sex. The first group received oral vitamin D3 2000IU/day for 6 months and the second group received placebo for 6 months. Vitamin D status as well as different IBS score systems (IBS-SSS, IBS-QoL, and total score) were evaluated before and 6 months after treatment.

Results:

IBS patients who received vitamin D supplementation for 6 months showed significant improvement in IBS-SSS (P < 0.001), IBS-QoL (P < 0.001), and total score (P = 0.02) compared to IBS placebo group. IBS patients treated with vitamin D showed two folds increase in their serum vitamin D levels (from 17.2 ± 1.3 to 39 ± 3.3) ng/ml with P < 0.001. While in the placebo group, their serum vitamin D levels were not significantly changed (P = 0.66). Vitamin D was tolerated well without any recorded adverse effects during the study period.

Conclusion:

Vitamin D supplementation can be effective in treating adolescents with IBS and vitamin D deficiency.

KEYWORDS:

Adolescents; irritable bowel syndrome; vitamin D

PMID:
29637918
PMCID:
PMC5900470
DOI:
10.4103/sjg.SJG_438_17
[Indexed for MEDLINE]
Free PMC Article

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