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FEBS J. 2018 Sep;285(17):3138-3151. doi: 10.1111/febs.14465. Epub 2018 Apr 30.

Interactions of the immune and sensory nervous systems in atopy.

Oetjen LK1,2, Kim BS1,2,3,4.

Author information

1
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.
2
Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
3
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
4
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Abstract

A striking feature underlying all atopic disorders, such as asthma, atopic dermatitis, and food allergy, is the presence of pathologic sensory responses, reflexes, and behaviors. These symptoms, exemplified by chronic airway irritation and cough, chronic itch and scratching, as well as gastrointestinal discomfort and dysfunction, are often cited as the most debilitating aspects of atopic disorders. Emerging studies have highlighted how the immune system shapes the scope and intensity of sensory responses by directly modulating the sensory nervous system. Additionally, factors produced by neurons have demonstrated novel functions in propagating atopic inflammation at barrier surfaces. In this review, we highlight new studies that have changed our understanding of atopy through advances in characterizing the reciprocal interactions between the immune and sensory nervous systems.

KEYWORDS:

allergy; asthma; atopic dermatitis; atopy; cytokine; neuroimmunology; sensory nervous system

PMID:
29637705
PMCID:
PMC6516504
DOI:
10.1111/febs.14465
[Indexed for MEDLINE]
Free PMC Article

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