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J Am Geriatr Soc. 2018 Jul;66(6):1172-1179. doi: 10.1111/jgs.15369. Epub 2018 Apr 10.

Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study.

Author information

1
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
2
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.
3
Department of Neurology, University of Michigan, Ann Arbor, Michigan.
4
Department of Radiology, University of Michigan, Ann Arbor, Michigan.
5
Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
6
School of Kinesiology, Louisiana State University, Baton Rouge, Louisiana.
7
Department of Health Research and Policy, Stanford University, Palo Alto, California.
8
Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida.
9
Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland.
10
Department of Geriatrics, School of Medicine, Yale University, New Haven, Connecticut.

Abstract

OBJECTIVES:

To determine whether intervention-induced physical activity (PA) changes in sedentary older adults differed according to dopamine-related genotype.

DESIGN:

Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial (2010-13)).

SETTING:

Multicenter study, 8 U.S.

LOCATIONS:

PARTICIPANTS:

Volunteer sample of sedentary adults aged 70 to 89 at risk of disability (N=1635).

INTERVENTIONS:

Structured PA versus health education (HE) for an average of 2.6 years.

MEASUREMENTS:

Single-nucleotide polymorphisms of dopamine-related genes (dopamine receptor (DR) D1, DRD2, DRD3, and catechol-O-methyltransferase (COMT)) were assessed. Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min/d) at baseline and 6, 12, and 24 months. Between-arm MVPA differences according to genotype and genotype with square root-transformed MVPA separately according to arm were tested, stratified according to race, and adjusted for multiple comparisons.

RESULTS:

White participants in the PA arm (n=513) had higher average square root transformed MVPA (4.91±1.91)than those in the HE arm (n=538) (4.51±1.82) (p=.001). Between-arm differences were greater for DRD2 Met/Met (high dopamine; HE: 4.76±1.80, PA: 5.53±1.60, p=.03) than Val/Val (low dopamine; HE: 4.58±1.92, PA: 4.81±1.83, p=.16); results were similar for COMT. In the PA arm, DRD2 Met/Met was associated with higher average MVPA (5.39±2.00) than Met/Val (4.46±2.51) (p=.01) and Val/Val (4.65±2.71) (p=.01). There were no associations for other genes. Associations were not significant in blacks but followed similar trends.

CONCLUSION:

Higher dopamine signaling may support changes in PA during an intervention. The role of dopamine-related pathways in promoting PA participation and enhancing response to interventions in sedentary older adults should be studied.

TRIAL REGISTRATION:

clinicaltrials.gov Identifier: NCT01072500.

KEYWORDS:

aging; dopamine; physical activity; randomized controlled trial

PMID:
29637543
PMCID:
PMC6105503
DOI:
10.1111/jgs.15369
[Indexed for MEDLINE]
Free PMC Article

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