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Am J Transl Res. 2018 Mar 15;10(3):648-658. eCollection 2018.

15d-PGJ2 is a new hope for controlling tumor growth.

Bie Q1,2, Dong H1, Jin C1, Zhang H1,3, Zhang B1,2.

Author information

1
Department of Laboratory Medicine, Affiliated Hospital of Jining Medical UniversityJining, Shandong, P. R. China.
2
Institute of Forensic Medicine and Laboratory Medicine, Jining Medical UniversityJining, Shandong, P. R. China.
3
Department of Hematology, Affiliated Hospital of Jining Medical UniversityJining, Shandong, P. R. China.

Abstract

15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a natural PPARγ agonist, has been investigated for over a decade. Studies have revealed that it has proapoptotic, anti-inflammatory, antiangiogenic, and anti-metastatic abilities, as well as a significant anticancer effect. However, the mechanisms underlying the actions of 15d-PGJ2 on various tumors are only partially known. In this review, we discuss the recent progress in elucidating these mechanisms. Understanding the various functions and mechanisms of 15d-PGJ2 are crucial for the development of new therapies for controlling tumor growth and providing the basis for further research.

KEYWORDS:

15d-PGJ2; Prostaglandins; angiogenesis; anti-inflammatory; apoptosis; metastasis

PMID:
29636856
PMCID:
PMC5883107

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