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Sci Rep. 2018 Apr 10;8(1):5779. doi: 10.1038/s41598-018-24146-z.

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves.

Author information

1
MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
2
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, TNLIST/Department of Automation, Tsinghua University, Beijing, 100084, China.
3
School of Data Sciences, Zhejiang University of Finance & Economics, Zhejiang, 310018, China.
4
MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, TNLIST/Department of Automation, Tsinghua University, Beijing, 100084, China. xwwang@tsinghua.edu.cn.
5
MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. zwang@tsinghua.edu.cn.

Abstract

Despite technological advances, the survival records from longevity experiments remain the most indispensable tool in ageing-related research. A variety of interventions, including medications, genetic manipulations and calorie restriction (CR), have been demonstrated to extend the lifespan of several species. Surprisingly, few systematic studies have investigated the differences among these anti-ageing strategies using survival data. Here, we conduct a comprehensive and comparative meta-analysis of numerous published studies on Caenorhabditis elegans and Drosophila. We found that CR and genetic manipulations are generally more effective than medications at extending the total lifespan in both models, and CR can improve the ageing pattern of C. elegans. We further analysed the survival variation for different anti-ageing medications and determined that hypoglycaemic agents and antioxidants are advantageous despite only moderately increasing the overall lifespan; therefore, these two types of medications are promising CR mimetics. Analysis of genetic manipulations also indicated that the genes or pathways that extend lifespan in a healthier pattern are associated with CR. These results suggest that CR or CR mimetics may be the most reasonable and potentially beneficial anti-ageing strategy.

PMID:
29636552
PMCID:
PMC5893623
DOI:
10.1038/s41598-018-24146-z
[Indexed for MEDLINE]
Free PMC Article

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