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Mol Immunol. 2018 Apr 7. pii: S0161-5890(18)30106-8. doi: 10.1016/j.molimm.2018.03.027. [Epub ahead of print]

Antigen processing and presentation in HIV infection.

Author information

1
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States.
2
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States. Electronic address: sylvie_legall@hms.harvard.edu.

Abstract

The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.

KEYWORDS:

HIV; Immune escape; Immunopeptidome; Protein degradation; T cells; Vaccine immunogen design

PMID:
29636181
PMCID:
PMC6174111
[Available on 2019-10-07]
DOI:
10.1016/j.molimm.2018.03.027

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