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Lupus. 2018 Jun;27(7):1159-1168. doi: 10.1177/0961203318768880. Epub 2018 Apr 10.

Increased flexibility, pain reduction and unaltered levels of IL-10 and CD11b + lymphocytes in patients with systemic lupus erythematosus were associated with kinesiotherapy.

Author information

1
1 Discipline of Special Pathology, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.
2
2 Department of Applied Physical Therapy, Institute of Health Sciences, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.
3
3 Department of Biochemistry, Pharmacology and Physiology, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.
4
4 Research Institute of Oncology (IPON)/Discipline of Gynecology and Obstetrics, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.
5
5 Discipline of Rheumatology, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.

Abstract

The effect of physical activity on the immune system is still poorly understood in cases of systemic lupus erythematosus (SLE). Therefore, our aim was to investigate differences in the serum levels of cytokines (IL-2, IL-5, IL-6, IL-8, IL-10 and TNF-α) and the numbers of CD11b + and CXCR2 + neutrophils and lymphocytes in women with SLE undergoing drug treatment, without ( n = 9) or with ( n = 5) 4 months of kinesiotherapy. Parameters related to functional capacity were also analyzed. In the case of the patients who were not submitted to kinesiotherapy, there were reductions in the levels of IL-5, IL-6 and IL-10, and an increase in the number of CD11b + leukocytes, in addition to an increase in abdominal circumference after the monitoring time. Patients submitted to kinesiotherapy did not present changes in serum cytokines or in the numbers of CD11b + and CXCR2 + neutrophils and lymphocytes, but there were increases of flexibility and strength, as well as a reduction in pain sensation after the monitoring time. In conclusion, kinesiotherapy was able to increase flexibility and reduce pain in SLE patients without influencing immune parameters.

KEYWORDS:

CD11b; CXCR2; Systemic lupus erythematosus; cytokines; functional capacity; kinesiotherapy; phagocytosis; physical exercise

PMID:
29635996
DOI:
10.1177/0961203318768880
[Indexed for MEDLINE]

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