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J Periodontol. 2018 Aug;89(8):973-982. doi: 10.1002/JPER.17-0613.

Gingival crevicular fluid and salivary resistin and tumor necrosis factor-alpha levels in obese children with gingivitis.

Author information

1
Department of Pediatric Dentistry, Faculty of Dentistry, Adnan Menderes University, Aydın, Turkey.
2
Department of Periodontology, Faculty of Dentistry, Adnan Menderes University, Aydın, Turkey.
3
Section of Molecular Biology, Department of Biology, Faculty of Science and Letters, Celal Bayar University, Manisa, Turkey.

Abstract

BACKGROUND:

This study aimed to evaluate the levels of resistin and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) and saliva of obese children with gingivitis.

METHODS:

One-hundred and thirty children (65 obese and 65 normal weight; age range 8 to 12 years) were recruited for the study. The children were classified into four subgroups based on their body mass and periodontal status; 1) obese children with gingivitis (OG, n = 33); 2) obese children with healthy periodontium (OH, n = 32); 3) normal weight children with gingivitis (NWG, n = 32); 4) normal weight children with healthy periodontium (NWH, n = 33). Body mass index (BMI) percentile, probing pocket depth (PPD), gingival index (GI), and plaque index (PI) were recorded. Resistin and TNF-α were analyzed in GCF and saliva samples by ELISA.

RESULTS:

Obese children had higher BMI percentiles than normal weight children (p < 0.0001). PPD, GI, PI, GCF volume, GCF, and salivary resistin and TNF-α levels were similar between obese and normal weight children (P > 0.05). OG and NWG subgroups had significantly higher GI, PI, GCF volume, GCF resistin total amounts, and salivary resistin concentrations but lower GCF resistin and TNF-α concentrations than OH and NWH (P < 0.0001 for all). GCF resistin total amounts were positively correlated with GI, PI, and GCF TNF-α total amounts (P < 0.05).

CONCLUSIONS:

To our knowledge, this is the first study evaluated the levels of resistin in GCF and saliva of children. Obesity is not associated with GCF and salivary resistin and TNF-α levels in children in the presence of gingival inflammation.

KEYWORDS:

cytokine(s); gingival crevicular fluid; gingivitis; obesity; saliva

PMID:
29635809
DOI:
10.1002/JPER.17-0613

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