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Chemosphere. 2018 Jul;203:467-473. doi: 10.1016/j.chemosphere.2018.03.186. Epub 2018 Mar 28.

Effects of triclosan in breast milk on the infant fecal microbiome.

Author information

1
Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA. Electronic address: candace.bever@ars.usda.gov.
2
Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA.
3
Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.
4
Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA; Department of Viticulture and Enology, University of California Davis, Davis, CA 95616, USA.
5
Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA; Foods for Health Institute, University of California Davis, Davis, CA 95616, USA.
6
Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, USA. Electronic address: bdhammock@ucdavis.edu.

Abstract

Triclosan is frequently used for its antimicrobial properties and has been detected in human serum, urine, and breast milk. Animal and molecular studies have shown that triclosan exerts a wide range of adverse health effects at both high (ppm) and low (ppb) concentrations. Since triclosan is of growing concern to human and environmental health, there is a need to improve extraction procedures and to study additional effects from triclosan exposure. In this study, we have improved triclosan extraction from breast milk by using salt (MgSO4) to reduce emulsion formation and increase water polarity and water (∼80%) to enhance the overall extraction efficiency (∼3.5 fold). This extraction method was applied to breast milk samples collected from donors who i) recorded their use of triclosan-containing personal care products and ii) provided matching infant stool samples. Of the participants who had detectable amounts of triclosan in their breast milk, nine (75%) of them reported daily use of triclosan-containing personal care products. Levels of triclosan in breast milk were compared to the donor's infant's fecal microbiome. We found that the bacterial diversity in the fecal microbiome of the infants exposed to breast milk with detectable triclosan levels differed compared to their peers exposed to milk containing non-detectable amounts. This finding implies that exogenous chemicals are impacting microbiome diversity.

KEYWORDS:

Breast milk; Fecal microbiome; Infant; Personal care products; Triclosan

PMID:
29635158
PMCID:
PMC5915298
DOI:
10.1016/j.chemosphere.2018.03.186
[Indexed for MEDLINE]
Free PMC Article

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