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J Clin Child Adolesc Psychol. 2018 May-Jun;47(3):483-497. doi: 10.1080/15374416.2018.1443461. Epub 2018 Apr 10.

Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders.

Author information

a Department of Psychology , University of Miami.
b Neuroscience Program , University of Miami Miller School of Medicine.
c NeuroImaging Network , Universal Scientific Education and Research Network.
d Departments of Psychology and Psychiatry , University of California Los Angeles.


Neurodevelopmental disorders are associated with atypical development and maturation of brain networks. A recent focus on human connectomics research and the growing popularity of open science initiatives has created the ideal climate in which to make real progress toward understanding the neurobiology of disorders affecting youth. Here we outline future directions for neuroscience researchers examining brain networks in neurodevelopmental disorders, highlighting gaps in the current literature. We emphasize the importance of leveraging large neuroimaging and phenotypic data sets recently made available to the research community, and we suggest specific novel methodological approaches, including analysis of brain dynamics and structural connectivity, that have the potential to produce the greatest clinical insight. Transdiagnostic approaches will also become increasingly necessary as the Research Domain Criteria framework put forth by the National Institute of Mental Health permeates scientific discourse. During this exciting era of big data and increased computational sophistication of analytic tools, the possibilities for significant advancement in understanding neurodevelopmental disorders are limitless.

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