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Aging Ment Health. 2019 Jul;23(7):880-886. doi: 10.1080/13607863.2018.1455167. Epub 2018 Apr 10.

Depression in type 1 diabetes and risk of dementia.

Author information

1
a Kaiser Permanente Division of Research , Oakland , CA , USA.
2
b Department of Epidemiology and Biostatistics , University of California, San Francisco , San Francisco , CA , USA.
3
c Department of Psychiatry , Icahn School of Medicine at Mount Sinai , New York , NY , USA.
4
d The Joseph Sagol Neuroscience Center , Sheba Medical Center , Tel Hashomer, Ramat Gan , Israel.

Abstract

OBJECTIVE:

Depression afflicts 14% of individuals with type 1 diabetes (T1D). Depression is a robust risk factor for dementia but it is unknown if this holds true for individuals with T1D, who recently started living to an age conferring dementia risk. We examined if depression is a dementia risk factor among elderly individuals with T1D.

METHODS:

3,742 individuals with T1D age ≥50 were followed for dementia from 1/1/96-9/30/2015. Depression, dementia, and comorbidities were abstracted from electronic medical records. Cox proportional hazard models estimated the association between depression and dementia adjusting for demographics, glycosylated hemoglobin, severe dysglycemic epidsodes, stroke, heart disease, nephropathy, and end stage renal disease. The cumulative incidence of dementia by depression was estimated conditional on survival dementia-free to age 55.

RESULTS:

Five percent (N = 182) were diagnosed with dementia and 20% had baseline depression. Depression was associated with a 72% increase in dementia (fully adjusted HR = 1.72; 95% CI:1.12-2.65). The 25-year cumulative incidence of dementia was more than double for those with versus without depression (27% vs. 12%).

CONCLUSIONS:

For people with T1D, depression significantly increases dementia risk. Given the pervasiveness of depression in T1D, this has major implications for successful aging in this population recently living to old age.

KEYWORDS:

Type 1 diabetes; cohort; dementia; depression

PMID:
29634288
PMCID:
PMC6179940
[Available on 2020-07-01]
DOI:
10.1080/13607863.2018.1455167

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