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ACS Chem Neurosci. 2018 May 16;9(5):870-872. doi: 10.1021/acschemneuro.8b00149. Epub 2018 Apr 10.

Role of BRCA1 in Neuronal Death in Alzheimer's Disease.

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1
Laboratory of Neurogenetics, Department of Neurodegenerative Disorders , Mossakowski Medical Research Centre, Polish Academy of Sciences , 5 Pawinskiego Street , 02-106 Warsaw , Poland.

Abstract

Oxidative damage of DNA has recently been indicated as one of the strong pathogenic agent in Alzheimer's disease (AD). Oxidative stress induces numerous signaling pathways, including DNA damage response (DDR), associated with the breast cancer type 1 susceptibility protein (BRCA1) protein, known to date from numerous reports in the cancer field. In this Viewpoint, we discuss the latest discoveries related to the role of BRCA1 in the death of neurons in AD. We underline the role of BRCA1 in the development of neurons and speculate on the consequences of BRCA1 dysfunction in the dying brain. In general, this Viewpoint is in a line with several recent reports on the processes and players common at the molecular and genetic level for neurodegenerative and cancerous diseases.

KEYWORDS:

Alzheimer’s disease; BRCA1; DNA damage response; oxidative stress

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