Format

Send to

Choose Destination
J Leukoc Biol. 2018 Jul;104(1):61-67. doi: 10.1002/JLB.3MR1117-426R. Epub 2018 Apr 6.

Eosinophil and airway nerve interactions in asthma.

Author information

1
Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Abstract

Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons' activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils' effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.

KEYWORDS:

asthma; eosinophil; major basic protein; parasympathetic nerve; sensory nerve

PMID:
29633324
DOI:
10.1002/JLB.3MR1117-426R

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center