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Med Phys. 2018 Jun;45(6):2681-2688. doi: 10.1002/mp.12909. Epub 2018 Apr 25.

Fluorescence-guided surgery and intervention - An AAPM emerging technology blue paper.

Author information

1
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
2
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
3
Institute of Biological and Medical Imaging, HelmholtzZentrum Munchen, Munich, Germany.
4
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
5
US Food and Drug Administration, Silver Spring, MD, USA.
6
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
7
National Institute of Standards and Technology, Gaithersburg, MD, USA.
8
Physikalisch-Technische Bundesanstalt, Berlin, Germany.
9
Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
10
Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA.
11
Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.
12
Department of Physics, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Fluorescence-guided surgery (FGS) and other interventions are rapidly evolving as a class of technologically driven interventional approaches in which many surgical specialties visualize fluorescent molecular tracers or biomarkers through associated cameras or oculars to guide clinical decisions on pathological lesion detection and excision/ablation. The technology has been commercialized for some specific applications, but also presents technical challenges unique to optical imaging that could confound the utility of some interventional procedures where real-time decisions must be made. Accordingly, the AAPM has initiated the publication of this Blue Paper of The Emerging Technology Working Group (TETAWG) and the creation of a Task Group from the Therapy Physics Committee within the Treatment Delivery Subcommittee. In describing the relevant issues, this document outlines the key parameters, stakeholders, impacts, and outcomes of clinical FGS technology and its applications. The presentation is not intended to be conclusive, but rather to inform the field of medical physics and stimulate the discussions needed in the field with respect to a seemingly low-risk imaging technology that has high potential for significant therapeutic impact. This AAPM Task Group is working toward consensus around guidelines and standards for advancing the field safely and effectively.

KEYWORDS:

imaging; imaging system; intervention; molecular; molecular probe; resection

PMID:
29633297
DOI:
10.1002/mp.12909
[Indexed for MEDLINE]

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