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ACS Cent Sci. 2018 Mar 28;4(3):405-412. doi: 10.1021/acscentsci.8b00008. Epub 2018 Mar 7.

A Compass at Weak Magnetic Fields Using Thymine Dimer Repair.

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Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Departments of Chemistry and Physics, The Ohio State University, Columbus, Ohio 43210, United States.


How birds sense the variations in Earth's magnetic field for navigation is poorly understood, although cryptochromes, proteins homologous to photolyases, have been proposed to participate in this magnetic sensing. Here, in electrochemical studies with an applied magnetic field, we monitor the repair of cyclobutane pyrimidine dimer lesions in duplex DNA by photolyase, mutants of photolyase, and a modified cryptochrome. We find that the yield of dimer repair is dependent on the strength and angle of the applied magnetic field even when using magnetic fields weaker than 1 gauss. This high sensitivity to weak magnetic fields depends upon a fast radical pair reaction on the thymines leading to repair. These data illustrate chemically how cyclobutane pyrimidine dimer repair may be used in a biological compass informed by variations in Earth's magnetic field.

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