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Nat Commun. 2018 Apr 9;9(1):1347. doi: 10.1038/s41467-018-03837-1.

Stimulus dependent diversity and stereotypy in the output of an olfactory functional unit.

Author information

1
Neuroscience Institute, NYU Langone Health, 435 E 30h St, New York, NY, 10016, USA.
2
Biocircuits Institute, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, USA.
3
Center for Neural Science, New York University, 4 Washington Place, New York, NY, 10003, USA.
4
Howard Hughes Medical Institute, New York, 10003, NY, USA.
5
DeepMind, 6 Pancras Square, London, N1C 4AG, UK.
6
Department of Neurobiology, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA.
7
Neuroscience Institute, NYU Langone Health, 435 E 30h St, New York, NY, 10016, USA. rinberg@nyu.edu.
8
Center for Neural Science, New York University, 4 Washington Place, New York, NY, 10003, USA. rinberg@nyu.edu.

Abstract

Olfactory inputs are organized in an array of functional units (glomeruli), each relaying information from sensory neurons expressing a given odorant receptor to a small population of output neurons, mitral/tufted (MT) cells. MT cells respond heterogeneously to odorants, and how the responses encode stimulus features is unknown. We recorded in awake mice responses from "sister" MT cells that receive input from a functionally characterized, genetically identified glomerulus, corresponding to a specific receptor (M72). Despite receiving similar inputs, sister MT cells exhibit temporally diverse, concentration-dependent, excitatory and inhibitory responses to most M72 ligands. In contrast, the strongest known ligand for M72 elicits temporally stereotyped, early excitatory responses in sister MT cells, consistent across a range of concentrations. Our data suggest that information about ligand affinity is encoded in the collective stereotypy or diversity of activity among sister MT cells within a glomerular functional unit in a concentration-tolerant manner.

PMID:
29632302
PMCID:
PMC5890244
DOI:
10.1038/s41467-018-03837-1
[Indexed for MEDLINE]
Free PMC Article

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