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NIDA Res Monogr. 1986;75:555-8.

Central and peripheral beta-endorphin response to transcutaneous electrical nerve stimulation.

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Department of Obstetrics and Gynecology, University of Modena, Italy.


The effects of transcutaneous electrical nerve stimulation on plasma and cerebrospinal fluid (CSF) levels of beta-Endorphin (beta-EP) were studied in 6 groups of pain-free patients. Different modes of TENS were applied for 20 minutes. Regardless of mode and/or frequency of the stimulation plasma and/or CSF beta-EP levels were significantly increased. Plasma and CSF responses were not correlated suggesting that TENS activates different opiatergic pathways at central and peripheral level.

[Indexed for MEDLINE]

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