Format

Send to

Choose Destination
Food Chem Toxicol. 2018 Jun;116(Pt B):70-76. doi: 10.1016/j.fct.2018.04.005. Epub 2018 Apr 6.

Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1α accumulation and VEGF expression.

Author information

1
Department of Oncology, Korea University Guro Hospital, 148 Gurodong-gil, Guro-gu, Seoul 152-703, Republic of Korea.
2
Department of Oncology, Korea University Guro Hospital, 148 Gurodong-gil, Guro-gu, Seoul 152-703, Republic of Korea; Graduate School of Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
3
Department of Oncology, Korea University Guro Hospital, 148 Gurodong-gil, Guro-gu, Seoul 152-703, Republic of Korea; Graduate School of Medicine, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: neogene@korea.ac.kr.

Abstract

Hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) play important roles in cancer progression in various cancer cell lines. Although genipin, a constituent of Gardenia fruit, has been shown to have anti-tumor activity, its role in the suppression of HIF-1 and its downstream target genes is not well understood. We examined the effect of genipin on the intracellular level of HIF-1α and extracellular level of VEGF using the colon cancer cell line HCT116. We observed that genipin suppressed the accumulation of HIF-1α under hypoxia in various cancer cell lines, including HCT116, via the modulation of protein degradation. Genipin also suppressed the expression of VEGF and the invasion of colon cancer cells by blocking the extracellular signal-regulated kinase signaling pathway. Taken together, our results provide new insights into the potential role of genipin in suppressing colon cancer progression.

KEYWORDS:

Akt; ERK; Genipin; Hypoxia-inducible factor-1; Invasion; Vascular endothelial growth factor

PMID:
29630948
DOI:
10.1016/j.fct.2018.04.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center