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Hum Vaccin Immunother. 2018;14(8):2069-2074. doi: 10.1080/21645515.2018.1462068. Epub 2018 May 11.

The case for ring vaccinations with special consideration of oral cholera vaccines.

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a Institute of Child Health and Human Development, National Institutes of Health, University of the Philippines , Manila , Philippines.
b Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok , Thailand.


Ring vaccinations create a zone of immune contacts around a case to prevent further disease transmission and have been successfully employed in the eradication of smallpox and the control of other infections. Millions of oral cholera vaccine (OCV) doses have been effectively deployed through mass vaccination campaigns. But there are situations when the OCV supply, resources, and time are limited and alternative strategies need to be considered. People living in close proximity of cholera cases often share risk factors such as contaminated water supply and poor sanitation. Targeting people within a given radius around a cholera case for intervention including vaccination, improved water supply and sanitation may be a practical and effective approach. A ring oral cholera vaccination strategy could be considered before, after or as an alternative to a mass vaccination approach. We review here the use of the ring vaccinations in general and specifically during cholera outbreaks.


ring vaccination; oral cholera vaccine (OCV); cholera; targeted intervention

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